Retiming the failing heart: principles and current clinical status of cardiac resynchronization.

Identification of genetic markers for treatment success in heart failure patients: insight from cardiac resynchronization therapy.

BACKGROUND Cardiac resynchronization therapy (CRT) can improve ventricular size, shape, and mass and reduce mitral regurgitation by reverse remodeling of the failing ventricle. About 30% of patients do not respond to this therapy for unknown reasons. In this study, we aimed at the identification and classification of CRT responder by the use of genetic variants and clinical parameters. METHOD...

Heart failure monitoring with a cardiac resynchronization therapy device-based cardiac contractility sensor: a case series

INTRODUCTION The SonR signal has been shown to reflect cardiac contractility. It is recorded with an atrial lead connected to a cardiac resynchronization therapy defibrillator. For the first time, clinical evidence on the use of the SonR signal in the monitoring of the clinical status of heart failure patients implanted with cardiac resynchronization therapy defibrillator are presented through ...

Clinical Implication of Mechanical Dyssynchrony in Heart Failure

Mechanical dyssynchrony is a common phenomenon in patients with congestive heart failure, which usually identified by noninvasive cardiac imaging tools such as echocardiography. It demonstrates electromechanical delay in some regions of the failing heart which in turn contributes to further impairment of cardiac function. The diagnostic, therapeutic and prognostic values of mechanical dyssynchr...

[Cardiac resynchronization therapy: when the pacing site really matters].

Cardiac resynchronization therapy has been one of the major qualitative advances made in the treatment of heart failure in recent decades, and it strongly underlines the relationship between heart mechanics, hemodynamic function, and electrophysiology. Since the 1980s a number of clinical and experimental studies have shown that abnormalities in intraventricular conduction, associated or not wi...

Endocardial Left Ventricular Pacing Improves Cardiac Resynchronization Therapy in Chronic Asynchronous Infarction and Heart Failure Models Running title: Strik et al.; Endocardial CRT in infarcted and failing canine hearts